Click Here To Schedule A Consultation

Schedule a Consultation

  • Note: We do not offer virtual consultations
  • This field is for validation purposes and should be left unchanged.

One of the telltale signs of the aging process is that of fine lines and wrinkles on the face. Facial wrinkles such as laugh lines or frown lines can be a frustrating reality of getting older, and can often make us look older than we feel. Thankfully, recent innovations in the world of dermatology have allowed patients to experience total facial rejuvenation through procedures like Microneedling, skin resurfacing laser treatment, chemical peels, Botox injections and hyaluronic acid fillers. Dr. Michele Green in New York City was one of the first dermatologists to incorporate these dermal fillers, such as Restylane-l, Restylane Defyne and Restylane Refyne, into her discreet, private, NYC dermatology office.

Dermal fillers are injectable treatments that are designed to restore a youthful appearance to the skin, as well as replace volume loss within the treatment area. Injectable fillers, composed of hyaluronic acid, have become the gold standard when it comes to reducing the appearance of fine lines and wrinkles on the face. Hyaluronic acid dermal fillers use a naturally occurring substance in the body, hyaluronic acid, to naturally stimulate new collagen growth, leading to long term facial rejuvenation. With no downtime with these dermal fillers, facial rejuvenation can be accomplished in as little as thirty minutes. One of the biggest names in hyaluronic acid fillers is the Restylane line of dermal fillers, from pharmaceutical giant Galderma.

If you’re frustrated by the appearance of creases, fine lines, facial wrinkles, or chin recession, NYC-based board-certified dermatologist Dr. Michele Green is here to help. Dr. Green is an expert in cosmetic injections, with over 25 years of experience in cosmetic dermatology. With her less-is-more approach to facial augmentation and dermal fillers, Dr. Green is internationally known for providing patients with the most natural results in treating volume loss and facial wrinkles. Dr. Green is consistently voted as one of the best doctors in New York City by Castle Connolly, The New York Times, Super Doctors, and New York Magazine. If you are interested in a more youthful appearance with no downtime, Dr. Green is here to help.

What’s new in Restylane dermal fillers?

Pharmaceutical giant, Galderma, is consistently updating their Restylane products to provide patients with the next generation of innovative facial rejuvenation and augmentation options. The Restylane family is particularly notable for its proprietary XpresHAn technology, in which the unique cross-linking of the gel provides support to replace lost volume and collagen while allowing for natural movement of the face. Two such products that utilize this innovative technology are Restylane Defyne and Restylane Refyne. Both Restylane Defyne and Restylane Refyne are designed specifically for use in eliminating nasolabial lines, which run from the side of the nose to the corners of your mouth, and marionette lines, which are creases that go from the corners of your mouth down to your chin. The individual results of the two products differ due to the amount of cross-linking that is found in the gel: Restylane Refyne is best for mild-to-moderate lines due to its more flexible nature, whereas Restylane Defyne is best used for moderate-to-severe facial wrinkles, as it provides more support.

Two other Restylane products that have recently become FDA approved for use in the United States are Restylane Kysse and Restylane Contour. For patients who aspire to plump, kissable lips with the perfect pout, Restylane Kysse is the ideal option. FDA approved as of May 2020, Restylane Kysse is now being used to increase the volume of the lips, create a smooth texture, eliminate fine lines, and enhance the color of the lips. Dr. Green’s office was one of the first to adopt Restylane Kysse into use after approval and as an expert lip filler, Dr. Green has had photographs of her lip injections used in such publications as Glamour Magazine and the New York Times. Dr. Green has also quickly adopted the newest member of the Restylane family, Restylane Contour, which was approved in June of 2021 for use in the mid-face. Restylane Contour also uses the XpresHAn technology to create more prominent cheekbones, eliminate wrinkles in the mid-face, and provide a firm texture to the skin, all to provide patients with a more youthful appearance.

What is Restylane® Refyne?

Restylane Refyne is a hyaluronic acid filler that reduces moderate-to-severe signs of aging around the nose and mouth. Similarly to Restylane Defyne, it uses XpresHAn technology which allows the hyaluronic acid to cross-link with the skin cells, creating an incredibly natural look. The new XpresHAn Technology allows the Hyaluronic Acid gel to flex within your skin to move as you move your face. No matter what type of facial expression you make, whether it be smiling or frowning, the filler will not appear stiff or lumpy and the results will appear soft and natural. Though Restylane Refyne was only recently approved by the FDA, it has been used in Europe for anti-aging treatments since 2010 under the name Emervel..

KC restylane nasolabial before after FRONT 2 MGwatermark

Female treated with Restylane in nasolabial folds

How long does Restylane Refyne last?

Restylane Refyne is an innovative, long-lasting injectable that will help to reduce the appearance of fine lines and facial winkles, as well as improve chin projection, with results that last. Though all dermal fillers are considered temporary treatments, patients who engage with Restylane Refyne treatment can expect improved elasticity, facial rejuvenation, and a natural look that last up to a full year.

Who is a good candidate for Restylane Refyne?

A good candidate for Restylane Refyne is one who has moderate-to-severe facial wrinkles and folds, or who is interested in chin augmentation. Patients must be above the age of 21 to receive Restylane dermal fillers, but in general healthy patients seeking facial rejuvenation without the need for downtime qualify for injectable hyaluronic acid filler treatment. Patients who are pregnant or are currently breastfeeding, have a history of severe allergies to lidocaine or gram-positive bacterial proteins, have a bleeding disorder, or take medications that affect bleeding and clotting (i.e. Aspirin, Warfarin) may be contraindicated for Restylane injections, so it’s best to discuss these factors with Dr. Green prior to treatment.

A good candidate for Restylane Defyne or Restylane Refyne is anyone who is struggling with the appearance of folds and wrinkles around the nose and mouth. In general, Restylane products are safe to use and have incredibly minimal side effects, if any, including mild swelling or redness at the injection site. However, if you have severe allergies to lidocaine (a numbing agent), have a bleeding disorder, are pregnant, or are currently breastfeeding, Restylane Defyne and Restylane Refyne are contraindicated.

The most important part of treatment for any injectable is who you choose to be your injector. Medical spas often have inexperienced injectors which can lead to more serious side effects, such as the risk of infection or the unintentional injection of filler into a blood vessel. For this reason, your cosmetic dermal filler injections should always be done by a expert, board-certified dermatologist. Dr. Green is an experienced, artful injector who will make sure that the experience is as comfortable, safe, and satisfactory as possible.

How long do Restylane Refyne injections last?

Restylane Refyne is designed to treat mild-to-moderate lines and wrinkles around the nose, mouth, and chin. The flexible cross-linking gel boosts collagen and hyaluronic acid production in the face for a natural, youthful look. While the results of any dermal filler are not permanent, Restylane Refyne provides long-lasting and effective results. Similarly to Restylane Defyne, the effects of Restylane Refyne can be seen for up to a year following the treatment. Once the results have worn off, the procedure can be repeated in order to maintain the smooth, firm texture and look of the skin.



What is Restylane Refyne used for?

Restylane Refyne is typically used to treat nasolabial folds, which run from the sides of your nose down to the corners of your mouth; marionette lines, which extend from the corners of the mouth down to the chin), and other wrinkles around the nose and mouth. Its innovative design allows Restylane Refyne to reduce the appearance of facial lines while maintaining a natural look and natural movement.

Can Restylane Refyne be used for laugh lines?

Restylane Refyne is tailor made to treat laugh lines or smile lines, also known as nasolabial folds, as well as frown lines or marionette lines. Restylane Refyne’s XpresHAn technology relies on unique cross-linking of the gel in order to best add volume and smooth the skin of the treatment area. This innovative technology makes for volume-boosting and natural results that require zero downtime.

Can Restylane Refyne be used in lips?

Though Restylane Refyne is an excellent treatment for mild-to-moderate facial wrinkles and folds around the mouth and nose, it is not typically used for lip augmentation. For optimal lip augmentation, Dr. Green recommends Restylane Silk, Restylane Kysse, or Juvederm Ultra Plus, which are all tailor made for the best lip enhancement. Dr. Green is known as the “lip queen” for her perfect pouts and lip augmentation results. When you consult with Dr. Green, she will develop a customize treatment plan for you to determine the best dermal filler treatment to meet your personal cosmetic goals.

Which Restylane filler is best for lips?

The best hyaluronic acid dermal filler depends entirely on the individual needs and goals of each patient. Some patient want a more subtle lip augmentation and others are looking for a more dramatic lip enhancement. Due to these personal variations and desires, Dr. Green offers a variety of different Restylane and  Juvederm hyaluronic acid fillers to make sure that she can tailor individual treatment to each of her patients. These include Restylane Silk, Restylane Kysse, Juvederm Ultra Plus, Juvederm Volbella, and Belotero Balance. Learn more about dermal filler lip augmentation.

As each individual patient has unique needs and aesthetic goals, there is no one “best” dermal filler to treat the lips. However, Restylane-L, Restylane Silk, and Restylane Kysse are all excellent options for both lip rejuvenation and lip augmentation. Restylane-L is most similar to the original Restylane formulation, which is an excellent option for patients looking to reduce the appearance of fine lines at the edges of the lips. Restylane Silk is a unique filler treatment that can be applied to both the lips and the fine lines around the lip area, and relies on an innovative, small particle size to help Dr. Green achieve a precise lip contour. Restylane Kysse is the newest lip enhancement formulation from Restylane, and offers patients up to a full year in lip fullness, one of the longest-lasting lip fillers on the market. Additionally, Restylane Silk and Restylane Kysse are both excellent options for patients treating perioral lines (vertical lip lines).  Dr. Green can discuss all of your available lip enhancement and anti-aging solutions, and help you to select the treatment options that are right for you.

refyne 1079654975

What is the difference between Restylane Refyne and Defyne?

Restylane Refyne and Restylane Defyne are both designed to radically improve the look of facial wrinkles and deep folds, and rely on unique cross-linking technology in order to create an incredibly natural appearance. Restylane Defyne and Restylane Refyne are the only fillers on the market that have been shown in clinical study to help maintain movement and natural expressions.

The primary difference between Restylane Defyne and Restylane Refyne is the level of depth each is designed to treat. Typically, Restylane Refyne is used to treat mild-to-moderate facial wrinkles and folds, whereas Restylane Defyne is best for moderate-to-severe facial wrinkles and folds. Both Restylane Refyne and Restylane Defyne have unique cross-linking technology to correct volume loss, but the two formulations create flexibility when it comes to reducing a variety of fine lines and wrinkles due to the natural aging process.

The key difference between Restylane® Refyne and Restylane® Defyne is that they differ in the amount of cross-linking found within the gel, which determines the amount of flexibility and support that the gels provides. Simply, Restylane® Refyne is a more flexible gel, whereas Restylane® Defyne is a more supportive gel, which can be used together to enhance and treat these deeper lines and wrinkles.

How much is​​​​ Restylane Refyne?

When it comes to how much is Restylane Defyne or Restylane Refyne, the price varies widely depending on the individual needs and goals of each patient. When you meet with Dr. Green for your initial consultation, she will work with you to discuss your individual needs and goals, and will develop a treatment plan that balances your budget and your desires.

Can Restylane Refyne be combined with other anti-aging or skin care procedures?

Restylane Refyne and Restylane Defyne can both be combined with other anti-aging or skin care procedures. Often, patients are interested in using complementary injectables such as Botox or Dysport for pan-facial rejuvenation, which can create a “liquid facelift.” Dr. Green is an expert in anti-aging and rejuvenating skin care procedures, including laser treatments, Fraxel, chemical peelsThermageCoolSculptingKybella, and other injectables.

Can Restylane Refyne be used under eyes for tear trough?

Though Restylane Refyne is an excellent option for patients seeking treatment for nasolabial folds, frown lines, marionette lines, and other facial wrinkles, it is not recommended for use under the eyes. This is because Restylane Refyne’s volume-boosting formulation is not designed for a delicate area like the tear trough. However, Restylane does offer a myriad of dermal fillers that are each designed for tailored use, and Restylane-L is an excellent option for patients seeking under eye rejuvenation. Due to its delicate formulation and design, Restylane-L is a popular option to restore volume under the eyes.

How long does Restylane Refyne last under eyes/tear trough?

As Restylane Refyne has a thicker formulation than other Restylane products, it’s best to avoid use of Restylane Refyne under the eyes or in the tear trough area. However, Restylane-L is an excellent option for patients seeking to correct volume loss in the under eye area, and results can last up to a full year. Patients who engage with under eye dermal filler tend to experience long-lasting results, as facial expressions don’t tend to engage the muscles in the under eye area as much as other areas of the face.

refyne still

Which Restylane is best for the chin?

Restylane offers two innovative formulations that both work to improve the profile of the chin: Restylane Defyne and Restylane Lyft. Both are FDA-approved for use to improve chin projection and create a striking, revitalized look for the structure of the face. When it comes to which Restylane is best, the answer varies depending on the individual needs and goals of the patient. When you work with Dr. Green, she’ll be able to determine which formulation will be best to fit your needs.

How long does Restylane Refyne last in lips?

Restylane Refyne, similarly to Restylane Defyne, is designed specifically for use on the nasolabial folds, marionette lines, and for chin augmentation. When it comes to the ideal Restylane product for lip augmentation, Dr. Green often recommends the use of Restylane Kysse. Restylane Kysse is perfect for creating the appearance of hydrated, plump lips, with enhanced and improved coloration. As Restylane Kysse is specifically designed to treat the lips, less of the product needs to be used in order to reach the best results compared to other hyaluronic acid fillers. Restylane Kysse is a long-lasting product for lip augmentation, with results that can remain for nine months to a year. When you consult with Dr. Green, you will be able to discuss with her your cosmetic goals and she will recommend the dermal filler product best suited to providing you with the results you want.

Are Restylane Refyne injections painful?

You may be wondering, do Restylane Refyne injections hurt? Like any injection, there may be some mild discomfort at the injection site. However, Restylane Refyne’s formulation includes lidocaine, which helps to minimize any patient discomfort during the procedure. In addition, a topical numbing cream can be applied to skin prior to your treatment to ensure that discomfort is virtually nonexistent. As injections can occasionally cause bruising or swelling along the dermis, Dr. Green recommends patients avoid the use of any blood thinning medications for a week prior to treatment. For patients who tend to bruise easily, an oral supplement called Arnika can be used to help prevent and resolve any bruising that may occur. Patients should start taking Arnika 1-2 days before their dermal filler treatment, and can continue using it in the days following the procedure until bruising has resolved.

Does Restylane Refyne have side effects?

When injected by board certified dermatologist Dr. Michele Green, dermal filler treatment with Restylane Refyne is a safe and effective procedure to eliminate fine lines and wrinkles on the face. While some patients may experience side effects, they are generally mild and resolve quickly. Side effects of Restylane Refyne may include swelling, redness, bruising, and itching at or near the injection site. Any discomfort, tenderness, or other side effects tend to go away on their own after 1-2 weeks following initial treatment. Patients should not receive Restylane Refyne injections if they have a history of severe allergic reactions, have an allergy to lidocaine, which is found in the injection solution, or if they are pregnant or breastfeeding. If you are experiencing any infection, hives, or herpetic outbreak, it is best to wait until after they heal before seeking Restylane Refyne dermal filler treatment.

37 year old female treated with Dysport & Restylane Refyne for Crows Feet and Forehead 11’s

How do I get started with Restylane Refyne injections today?

If you’re frustrated by facial volume loss, or fine lines and wrinkles on your skin, cosmetic injectables may be just the non-invasive treatment solution for you. The Restylane family of dermal fillers is composed of various dermal filler products, each with its own unique formulation that makes it best suited for different concerns and treatment areas. Restylane Refyne is particularly well suited for the lower face, including the nasolabial lines, marionette lines, lips, and jowl area. Dr. Michele Green is a board certified cosmetic dermatologist based in New York City with over 25 years of experience providing her patients from around the world with the best facial cosmetic injections. As a leader in NYC in the field of cosmetic dermatology, she will create a customized skin care and cosmetic rejuvenation plan for you. Please contact us online today or call our NYC office at 212-535-3088 to learn more about whether Restylane® Refyne may be the best treatment for you to look and feel like the very best version of yourself.

Related Topics

Call Us (212) 535-3088