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As we age, our skin starts to lose collagen, and this volume loss – combined with the development of fine lines and wrinkles – starts to show the visible signs of aging. Non-invasive injectable treatments, with Botox and dermal fillers, like Restylane Refyne and Juvederm, have become a popular approach to reducing facial lines and hollows.

Restylane Refyne is the next-generation hyaluronic acid filler that is designed to create younger-looking skin. It’s FDA-approved to correct the appearance of nasolabial folds, marionette lines, and other wrinkles around the nose and mouth. Its XpresHAn Technology uses innovative cross-linking to replace lost volume with a natural appearance, and allow natural movement after cosmetic injection. Restylane Refyne, and the family of Restylane fillers, will create a more youthful appearance, which requires zero downtime, during a single treatment.

Dr. Michele Green is an expert in cosmetic injections, with over 25 years of experience in cosmetic dermatology. Voted consistently as one of the best doctors in NYC by Castle Connolly and Super Doctors, her “less is more” philosophy and natural approach to cosmetic procedures, make her a favorite injector in New York. From lip augmentation and cheek augmentation and nasolabial folds, to Botox and laser treatments, Dr. Green has an artistic eye, and will give you the very best cosmetic results for your non-invasive cosmetic treatment.

KC restylane nasolabial before after FRONT 2 MGwatermark

Female treated with Restylane in nasolabial folds

What is Restylane® Refyne?

Restylane Refyne is an innovative dermal filler that’s designed to reduce the appearance of fine lines and wrinkles by correcting age-related volume loss that can create deeper creases in the skin. It’s a part of Galderma’s Restylane family of hyaluronic acid fillers, all with unique formulations to best target different areas of facial contouring. The Restylane products include Restylane L, Restylane Lyft,  Restylane Silk, Restylane Kysse, and Restylane Defyne.

A Hyaluronic acid (HA) dermal filler is a gel that is based around a naturally-occurring substance found in the body. It is a transparent substance that is injected in the skin, which in turn creates additional volume within the skin resulting in the smoothing out and reshaping of the lines and wrinkles. Hyaluronic acid dermal fillers are often used on the face to provide a more youthful appearance and reduce the visible signs of aging.

Though Restylane Refyne was only recently approved by the FDA, it has been used in Europe for anti-aging treatments since 2010 under the name Emervel. Restylane Refyne uses its active ingredient, hyaluronic acid, to naturally increase collagen production in the skin, which is able to improve the elasticity of the skin and restore volume along the treatment area.


What is Restylane Refyne used for?

Restylane Refyne is typically used to treat nasolabial folds, which run from the sides of your nose down to the corners of your mouth; marionette lines, which extend from the corners of the mouth down to the chin), and other wrinkles around the nose and mouth. Its innovative design allows Restylane Refyne to reduce the appearance of facial lines while maintaining a natural look and natural movement.

Can Restylane Refyne be used for laugh lines?

Restylane Refyne is tailor made to treat laugh lines or smile lines, also known as nasolabial folds, as well as frown lines or marionette lines. Restylane Refyne’s XpresHAn technology relies on unique cross-linking of the gel in order to best add volume and smooth the skin of the treatment area. This innovative technology makes for volume-boosting and natural results that require zero downtime.

How long does Restylane Refyne last?

While all dermal fillers are non-permanent treatments, Restylane Refyne provides a natural look that has long-lasting results. The majority of patients enjoy a revitalized look that lasts up to one year.

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Can Restylane Refyne be used in lips?

Though Restylane Refyne is an excellent treatment for mild-to-moderate facial wrinkles and folds around the mouth and nose, it is not typically used for lip augmentation. For optimal lip augmentation, Dr. Green recommends Restylane Silk, Restylane Kysse, or Juvederm Ultra Plus, which are all tailor made for the best lip enhancement. Dr. Green is known as the “lip queen” for her perfect pouts and lip augmentation results. When you consult with Dr. Green, she will develop a customize treatment plan for you to determine the best dermal filler treatment to meet your personal cosmetic goals.

How long does Restylane Refyne last in lips?

Restylane Refyne is wonderful treatment for patients dealing with facial folds, wrinkles, and fine lines in the mouth area, but it’s not the best option for lip enhancement due to its thicker formulation. For patients seeking to reduce facial wrinkles and improve the look of their lips, Dr. Green is able to work with multiple dermal filler formulations to ensure total facial enhancement. In general, Restylane Silk and Restylane Kysse are wonderful options for lip augmentation, and can lead to plush looking lips for between nine months to a full year.

Which Restylane filler is best for lips?

The best hyaluronic acid dermal filler depends entirely on the individual needs and goals of each patient. Some patient want a more subtle lip augmentation and others are looking for a more dramatic lip enhancement. Due to these personal variations and desires, Dr. Green offers a variety of different Restylane and  Juvederm hyaluronic acid fillers to make sure that she can tailor individual treatment to each of her patients. These include Restylane Silk, Restylane Kysse, Juvederm Ultra Plus, Juvederm Volbella, and Belotero Balance. Learn more about dermal filler lip augmentation.

What is the difference between Restylane Refyne and Defyne?

Restylane Refyne and Restylane Defyne are both designed to radically improve the look of facial wrinkles and deep folds, and rely on unique cross-linking technology in order to create an incredibly natural appearance. Restylane Defyne and Restylane Refyne are the only fillers on the market that have been shown in clinical study to help maintain movement and natural expressions.

The primary difference between Restylane Defyne and Restylane Refyne is the level of depth each is designed to treat. Typically, Restylane Refyne is used to treat mild-to-moderate facial wrinkles and folds, whereas Restylane Defyne is best for moderate-to-severe facial wrinkles and folds. Both Restylane Refyne and Restylane Defyne have unique cross-linking technology to correct volume loss, but the two formulations create flexibility when it comes to reducing a variety of fine lines and wrinkles due to the natural aging process.

The key difference between Restylane® Refyne and Restylane® Defyne is that they differ in the amount of cross-linking found within the gel, which determines the amount of flexibility and support that the gels provides. Simply, Restylane® Refyne is a more flexible gel, whereas Restylane® Defyne is a more supportive gel, which can be used together to enhance and treat these deeper lines and wrinkles.

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How much is​​​​ Restylane Refyne?

When it comes to how much is Restylane Defyne or Restylane Refyne, the price varies widely depending on the individual needs and goals of each patient. When you meet with Dr. Green for your initial consultation, she will work with you to discuss your individual needs and goals, and will develop a treatment plan that balances your budget and your desires.


37 year old female treated with Dysport & Restylane Refyne for Crows Feet and Forehead 11’s

Who is a candidate for Restylane Refyne?

A good candidate for Restylane Defyne or Restylane Refyne is anyone who is struggling with the appearance of folds and wrinkles around the nose and mouth. In general, Restylane products are safe to use and have incredibly minimal side effects, if any, including mild swelling or redness at the injection site. However, if you have severe allergies to lidocaine (a numbing agent), have a bleeding disorder, are pregnant, or are currently breastfeeding, Restylane Defyne and Restylane Refyne are contraindicated.

The most important part of treatment for any injectable is who you choose to be your injector. Medical spas often have inexperienced injectors which can lead to more serious side effects, such as the risk of infection or the unintentional injection of filler into a blood vessel. For this reason, your cosmetic dermal filler injections should always be done by a expert, board-certified dermatologist. Dr. Green is an experienced, artful injector who will make sure that the experience is as comfortable, safe, and satisfactory as possible.

Can Restylane Refyne be combined with other anti-aging or skin care procedures?

Restylane Refyne and Restylane Defyne can both be combined with other anti-aging or skin care procedures. Often, patients are interested in using complementary injectables such as Botox or Dysport for pan-facial rejuvenation, which can create a “liquid facelift.” Dr. Green is an expert in anti-aging and rejuvenating skin care procedures, including laser treatments, Fraxel, chemical peelsThermageCoolSculptingKybella, and other injectables.

Can Restylane Refyne be used under eyes for tear trough?

Though Restylane Refyne is an excellent option for patients seeking treatment for nasolabial folds, frown lines, marionette lines, and other facial wrinkles, it is not recommended for us under the eyes. This is because Restylane Refyne’s volume-boosting formulation is not designed for a delicate area like the tear trough. However, Restylane does offer a myriad of dermal fillers that are each designed for tailored use, and Restylane-L is an excellent option for patients seeking under eye rejuvenation. Due to its delicate formulation and design, Restylane-L is a popular option to restore volume under the eyes.

How long does Restylane Refyne last under eyes/tear trough?

As Restylane Refyne has a ticker formulation than other Restylane products, it’s be to avoid use of Restylane Refyne under the eyes or in the tear trough area. However, Restylane-L is an excellent option for patients seeking to correct volume loss in the under eye area, and results can last up to a full year. Patients who engage with under eye dermal filler tend to experience long-lasting results, as facial expressions don’t tend to engage the muscles in the under eye area as much as other areas of the face.

How much is Restylane-L for under eyes?

The cost of Restylane hyaluronic acid filler in the under eye area varies depending on the amount of volume correction needed, as well as the desired goals of each individual patient. The cost is linked to the number of vials of Restylane needed for the procedure (as some patients may only need a single syringe for both eyes while others will need more intensive volume restoration), as well as the expertise of the injector. As hyaluronic acid filler for under eyes is an off-label treatment, it’s imperative you work directly with a board-certified medical professional, rather than a medical spa.

How do I get started with Restylane Refyne injections today?

If you’re frustrated by facial volume loss, or fine lines and wrinkles on your skin, Restylane Refyne or Restylane Defyne may be the perfect injectable for you. Dr. Green is a board certified dermatologist, with over 25 years of experience in facial cosmetic injections. As a leading cosmetic injector in NYC in cosmetic dermatology, she will create a customized skin care and treatment plan for you. Dr. Green utilizes Restylane Refyne to give you a natural look in keeping with her “less is more” philosophy. Contact us online today or call our NYC office at 212-535-3088 to learn more about whether Restylane® Refyne Dermal Fillers may be the best treatment for you.

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