Hyaluronidase Injections NYC

Hyaluronidase is an injectable enzyme used to reverse the effects of hyaluronic acid fillers. Dermal fillers are more popular than ever due to their ease of access, lack of downtime and side effects, and consistently stunning rejuvenation results. As dermal fillers have been a boon to cosmetic dermatology, patients may sometimes feel dissatisfied with the final results of their hyaluronic acid fillers. Too often, dermal fillers are injected by untrained or inexperienced injectors, leaving patients with poor cosmetic results. Improper injection techniques can leave patients unhappy with their cosmetic filler injections and can even cause them to want to have their treatment reversed. If you are dealing with an “overdone” look or are otherwise unhappy with the results of your hyaluronic acid fillers, having hyaluronidase injections with Dr. Michele Green in NYC can reverse the effects.

Hyaluronidase is a naturally occurring enzyme in the body that breaks down hyaluronic acid molecules. Hyaluronic acid is one of the most popular compounds used to make dermal fillers like Juvederm, Restylane, and Belotero. By injecting hyaluronidase into unwanted areas of hyaluronic acid fillers, these dermal filler injections can be dissolved and reversed, restoring your skin to its original condition before injection. Hyaluronidase injections are very safe and typically cause minimal side effects. Patients may need one or more hyaluronidase treatments to remove their unwanted dermal filler, depending on the type and amount initially injected. To get the best results from dermal fillers or hyaluronidase injections, it’s always best to consult with an experienced injector such as Dr. Michele Green.

Dr. Michele Green is an internationally renowned board-certified dermatologist with over two and a half decades of experience providing some of the world’s most discerning individuals with the best non-invasive cosmetic treatment options, including dermal fillers and hyaluronidase injections. As an expert injector, Dr. Green takes a holistic approach and embraces a less-is-more philosophy in facial rejuvenation, customizing each patient’s treatment plan to best address their specific skin concerns and overall aesthetic goals. She is consistently recognized by Castle Connolly, New York Magazine, Super Doctors, and The New York Times as one of New York City’s best dermatologists for her dedication to her patients and expertise. If you need to correct misplaced hyaluronic acid fillers, Dr. Green can help.

What is hyaluronidase?

Hyaluronidase is an enzyme naturally produced by white blood cells that breaks down hyaluronic acid molecules. Hyaluronic acid is a glycosaminoglycan and a key component of the extracellular matrix, linking collagen fibers, connective tissue, and protein filaments to support skin hydration, moisture retention, and structure. By breaking down hyaluronic acid, hyaluronidase helps tissues move more easily through connective tissues. Both hyaluronidase and hyaluronic acid are commonly used in cosmetic dermatology for facial rejuvenation. Hyaluronic acid fillers are injected into the skin to restore lost volume and enhance contour and definition in areas such as the cheeks, lips, nasolabial folds, oral commissures, tear troughs (under the eyes), chin, and jawline. However, incorrect placement or injection technique can lead to undesirable cosmetic results. In such cases, hyaluronidase injections can dissolve hyaluronic acid molecules, removing the unwanted filler.

Hyaluronidase injections are available under several FDA-approved brand names, such as Hydase, Hylenex, Amphadase, and Vitrase. Hyaluronidase acts quickly, and patients often notice visible improvements within 24-48 hours. Sometimes, a second or third treatment may be necessary, depending on the type and amount of hyaluronic acid filler used initially. It’s important to note that hyaluronidase is ineffective on non-hyaluronic acid fillers like Radiesse or Sculptra, and you should discuss options with Dr. Green beforehand, as results can differ between patients. Dr. Michele Green, a board-certified dermatologist with over 25 years of experience in administering hyaluronic acid dermal fillers, can skillfully use hyaluronidase to help you restore your natural look if you’re dissatisfied with your fillers.

How does hyaluronidase work?

Hyaluronidase is an enzyme that breaks the links between hyaluronic acid molecules. Hyaluronic acid, also called hyaluronan, is a naturally occurring substance in the body mainly made of two sugar molecules, D-glucuronic acid and D-N-acetylglucosamine. Hyaluronidase cleaves the bonds between these two sugar molecules. Once broken, the hyaluronic acid molecules are divided into small fragments that the body’s natural processes can easily absorb. When injected into areas treated with hyaluronic acid dermal fillers, hyaluronidase binds to hyaluronic acid molecules, breaking them apart and dissolving the filler.

Is hyaluronidase injected into the subcutaneous tissue?

Yes, hyaluronidase is injected subcutaneously, or beneath the skin, to dissolve unwanted hyaluronic acid dermal fillers. When dermal fillers are injected, they are placed under the skin to enhance facial volume and shape. Incorrect placement, injection technique, or the use of the wrong filler in the treatment area can lead to undesirable cosmetic results or subcutaneous lumps and nodules. To dissolve the filler, an experienced injector will inject hyaluronidase into the same subcutaneous area to break down hyaluronic acid molecules and reverse its effects. When receiving hyaluronidase injections, it is crucial to consult an experienced, board-certified dermatologist, such as Dr. Michele Green in NYC, to ensure a safe and effective treatment.

What is hyaluronidase used for?

The Food and Drug Administration (FDA) has approved hyaluronidase injections for various treatments. In cosmetic dermatology, hyaluronidase is used to dissolve unwanted hyaluronic acid dermal fillers from the face. Patients may choose to dissolve their fillers due to an allergic reaction, delayed-onset nodules, HA-induced blindness, Tyndall effect (a bluish hue to the skin), vascular occlusion, or an undesirable cosmetic result.

The role of hyaluronidase in medical treatments is varied, and includes:

• Treating hypodermoclysis or fluid infusion through subcutaneous tissues (particularly in pediatric care)
• An adjuvant to accelerate the diffusion of drugs and local anesthetics subcutaneously, in regard to both dispersion and delivery
• Promoting absorption of contrast agents (dye) in urography (x-ray of blood or lymph vessels in the urinary tract)
• Edema reduction (off-label use)
• Vitreous hemorrhage
• Extravasation (fluid leakage) in chemotherapy patients to prevent tissue necrosis (cell death)
• Retrobulbar anesthesia within ophthalmic surgery
• Dissolving the effects of hyaluronic acid fillers, particularly incited by

Do hyaluronidase injections have any side effects?

Hyaluronidase injections for cosmetic purposes have very few side effects. The most common side effects are mild swelling, bruising, and tenderness at or near the injection sites, which usually resolve on their own within 1 to 2 weeks. Patients should avoid strenuous exercise and heat for 48 hours after treatment to help reduce swelling. They should also stop taking blood-thinning medications for one week before and after the injections to lower the risk of bruising.

The incidence of mild allergic reactions at the injection site is rare, with reported rates of 0.05% to 0.69%. A skin test can be done before your hyaluronidase injections to check for hypersensitivity. Recent studies show that hyaluronidase is antigenic, suggesting that repeated injections of relatively large amounts may lead to the formation of neutralizing antibodies. Consequently, hyaluronidase may become less effective at dissolving hyaluronic acid fillers with continued use. Additionally, hyaluronidase should not be injected intravenously, as this could pose risks for allergic reactions and other adverse events. Hyaluronidase is not recommended for patients who are currently pregnant or breastfeeding.

40-49 year old – Hyaluronidase 2 weeks before and after

Are there any drug interactions associated with hyaluronidase?

Drug interactions can occur when multiple medications are used at the same time, which may reduce the effectiveness of both treatments. In some cases, taking multiple medications can cause serious adverse events, making it essential to always inform Dr. Green of all medications you are taking before treatment. Hyaluronidase injections are not linked to serious side effects or interactions with other medications. However, receiving hyaluronidase injections while on medications like antihistamines may decrease the effectiveness of both treatments.

What is the process for getting hyaluronidase injections?

The first step in getting hyaluronidase injections is to consult with Dr. Green at her private dermatology office in NYC. She will evaluate your previous dermal filler results and discuss your concerns and aesthetic goals. She may also request records from your past dermal filler treatments to see which filler was used, how much was injected, and the injection sites. Dr. Green will review your medical and cosmetic history to determine if you are a good candidate for hyaluronidase injections. Photos will be taken to document your progress or treatment. Once your suitability is confirmed, she will explain the hyaluronidase injection process. The procedure may be performed the same day as your consultation or scheduled for a later date.

One hour before your procedure, a topical anesthetic cream will be applied to the treatment area to reduce discomfort. When you arrive at Dr. Green’s office, the skin will be sterilized and prepared for treatment. Dr. Green will then quickly and skillfully administer the hyaluronidase injections. An ice pack will be immediately applied to the area to decrease swelling. Patients note that the Hylenex injections may sting somewhat, although they are performed swiftly and the discomfort is minimal and brief. After the procedure, Dr. Green recommends that her patients return to her office two weeks after hyaluronidase injections. During this follow-up, it will be determined whether additional hyaluronidase is needed to dissolve the dermal fillers. Once all fillers are dissolved, a cosmetic treatment plan for future dermal fillers will be discussed with Dr. Green.

Does hyaluronidase work immediately?

Hyaluronidase works quickly and effectively to dissolve unwanted hyaluronic acid filler in the treated area. Hyaluronidase activity typically peaks at 48 hours, and many patients begin to see effects within 2-3 days after the procedure, with full results appearing around 2 weeks post-treatment. However, outcomes can vary depending on the density of the hyaluronic acid fillers used. Some fillers may require a higher dose or additional treatments to dissolve completely. There may be some swelling at the injection site, which can last up to two weeks. Therefore, Dr. Green recommends that patients wait 2 weeks before returning for a follow-up appointment, during which Dr. Green can evaluate the results of the initial hyaluronidase treatment and consider a second or third session if necessary.

How much hyaluronidase is needed to dissolve fillers?

The exact amount of hyaluronidase needed to dissolve your hyaluronic acid filler and reverse its effects can vary based on the type and amount of filler injected during your facial rejuvenation. If multiple syringes of HA filler are used in a dermal filler session, a patient might require several vials of hyaluronidase to dissolve the filler. Typically, a 1:1 ratio of hyaluronidase to hyaluronic acid dermal filler is needed to break down the hyaluronic acid. However, each patient is different and may need more hyaluronidase to dissolve their filler. For hyaluronic acid fillers that use cross-linking technology, multiple treatment sessions with hyaluronidase may be necessary to break the cross-links between hyaluronic acid molecules. Because of this, it is important to seek expert advice and administer hyaluronidase carefully. Dr. Michele Green in NYC customizes hyaluronidase injections based on her expertise and thorough knowledge of hyaluronic acid fillers. For each patient she treats with this injectable, she recommends a follow-up appointment about 2 weeks after the initial hyaluronidase treatment to assess if a second or third injection is needed to achieve optimal results.

Does hyaluronidase dissolve all fillers?

With so many fillers available, it can be hard to determine which ones hyaluronidase can dissolve, and many patients ask, “Will hyaluronidase dissolve all fillers?” Hyaluronidase injections break down only hyaluronic acid-based fillers, including popular brands such as Juvederm and Restylane. Fillers made from other substances, such as poly-L-lactic acid or calcium hydroxylapatite, cannot be dissolved with hyaluronidase. That’s why it’s essential to have an experienced, board-certified dermatologist—like Dr. Michele Green in NYC—perform your cosmetic injections to ensure safety and effectiveness. Dr. Green has over 25 years of experience offering some of the world’s most discerning individuals top-quality non-invasive cosmetic treatments, including dermal filler and hyaluronidase injections. She uses a holistic, less-is-more approach to facial rejuvenation, customizing each treatment plan to address the patient’s specific skin concerns and aesthetic goals.

How long after hyaluronidase can I get dermal fillers?

Patients should wait at least 2 weeks after their last hyaluronidase injection before receiving dermal fillers. By waiting two weeks, patients allow any side effects of the hyaluronidase injections, such as swelling, bruising, or tenderness at or near injection sites, to resolve. If you have hyaluronic acid filler injections too soon after hyaluronidase injections, there is a potential risk of the hyaluronidase dissolving the new dermal fillers. Dr. Green recommends that her patients fully reverse the effects of previously injected hyaluronic acid fillers before undergoing facial rejuvenation with cosmetic injectables, so they achieve optimal cosmetic results. When you consult with Dr. Green, she will work with you to establish a treatment plan and timeline that works best for you.

Do hyaluronidase injections work?

Yes! Hyaluronidase injections are highly effective at breaking down unwanted hyaluronic acid fillers in the skin. Numerous clinical studies and trials published in the Journal of Cosmetic Dermatology and Dermatol Surg have shown that the use of hyaluronidase injections effectively reverses the effects of various types of hyaluronic acid fillers. The number of treatment sessions needed to remove the filler depends on the type and amount initially injected. Some patients may achieve full clearance after just one session, while others may need multiple treatments for optimal results. Additionally, dermal fillers containing cross-linked hyaluronic acid often require several injections of hyaluronidase.

Is hyaluronidase safe?

Yes! Hyaluronidase is FDA-approved, meaning it has been proven safe and effective. Similar to Juvederm and Restylane, hyaluronidase injections are safe and have minimal side effects or contraindications. That said, you could potentially test it gradually over multiple treatment sessions, which can be arranged with cosmetic dermatologist Dr. Green in New York. Unlike procedures that use alternative substances such as Radiesse, Sculptra, or silicone oil fillers, hyaluronic acid fillers can be dissolved immediately after the procedure is done or months later. It is always important to have your hyaluronidase injections with an experienced, board-certified dermatologist like Dr. Green to ensure the best results while minimizing potential side effects. Hyaluronidase must be injected into the appropriate areas in precise amounts to prevent the dissolving of natural hyaluronic acid, which can result in crepey skin. Dr. Green is an expert injector with over 25 years of experience and will work with you to achieve your ideal aesthetic results.

Two treatments of Hyaluronidase under the eyes to dissolve improper Juvederm injections under her eyes (tear troughs)

Frequently Asked Questions (FAQs) About Hyaluronidase:

What is the function of the hyaluronidase enzyme?

Hyaluronidase has a variety of FDA-approved medical uses, including improving the diffusion of anesthetics in pain therapy, aiding the absorption of treatment agents in chemotherapeutics and ophthalmic surgery, serving as a spreading agent in subcutaneous injections, and, off-label, dissolving hyaluronic acid fillers. Different types of hyaluronidase work through different mechanisms of action, meaning the biochemical reactions that occur when hyaluronidase reacts with other substances in the body vary depending on the specific hyaluronidase enzyme used. Hyaluronidase breaks down glycosidic linkages via hydrolysis, a chemical reaction that uses water. By breaking down the glycosidic linkages of hyaluronic acid, hyaluronidase decreases the viscosity, or thickness, of hyaluronic acid molecules, facilitating their removal from the treatment area and making it highly effective at reversing the effects of poorly executed hyaluronic acid fillers.

What is hyaluronidase injection used for?

Hyaluronidase injections have many purposes. As an endoglycosidase, hyaluronidase breaks apart the chains of hyaluronic acid molecules so that they can be removed from the skin. This function allows hyaluronidase to have broad applications in the medical field. Hyaluronidase is most often used to dissolve HA dermal fillers and to improve the dispersion of injected drugs. Besides cosmetic use, hyaluronidase is used as an adjunct in subcutaneous urography to improve the resorption of radiopaque agents. To learn more about the various approved uses of hyaluronidase injections, you can view the label on the FDA website.

Where is hyaluronidase secreted and obtained from?

Hyaluronidase is a natural enzyme found in both bovine and human albumin. Hyaluronidase injections typically contain this enzyme collected from purified bovine tissue (ovine testicular hyaluronidase) or derived from human albumin sources (recombinant human hyaluronidase). It is isolated and purified before being used as an injectable drug in the medical field. Hyaluronidase is a highly complicated substance to create in injectable form and should never be attempted to be made at home. Hyaluronidase should only ever be administered by a board-certified medical professional, and only FDA-approved brands should be used. These brands include Hydase, Hylenex, Amphadase, and Vitrase. To ensure that a brand is FDA-approved for treatment, visit https://www.fda.gov/drugsatfda.

Under no circumstances should hyaluronidase be used from an unverified source. Brands like Hylenex use hyaluronidase derived from human albumin sources, which minimizes the risk of an allergic reaction. Dr. Green typically uses the Hylenex formulation for her hyaluronidase treatments, as she has found it reliable and consistent across a wide range of patient needs.

Is Hylenex the same as hyaluronidase?

Hylenex is one of the FDA-approved brand names for injectable subcutaneous fluid, hyaluronidase. Each brand name of hyaluronidase injections contains a unique dosage form of hyaluronidase. Hylenex is unique among FDA-approved hyaluronidase injectables in that it is the only product that does not contain any animal-derived materials. Rather, it is a synthetic, recombinant DNA product made from human products. Recombinant human hyaluronidase has a purity 100 times higher than some of the bovine preparations, and allergic reactions to Hylenex are very rare. Dr. Michele Green has over two and a half decades of experience with cosmetic injectables, including hyaluronic acid dermal fillers and hyaluronidase, and prefers to use Hylenex.

What is daratumumab hyaluronidase?

Darzalex Faspro is the brand name for the combination injection of daratumumab and hyaluronidase-fihj, used to treat newly diagnosed cases of bone marrow cancer, multiple myeloma. Specifically, daratumumab and hyaluronidase are combined when patients are eligible for an autologous stem cell transplant, meaning they can be treated with their own stem cells. Darzalex Faspro has not been adequately studied in patients who are breastfeeding and should be used with caution.

Does hyaluronidase dissolve Botox?

No. Botox is the gold standard for reducing dynamic fine lines and wrinkles. However, it cannot be dissolved by hyaluronidase. Botox is a neurotoxin, not a hyaluronic acid dermal filler. Only hyaluronic acid fillers can be dissolved with hyaluronidase. As a neurotoxin, Botox inhibits nerve signals to certain facial muscles related to expression, essentially “freezing” them to prevent overuse, ultimately leading to smoother skin texture and reduced visible fine lines. The effects of Botox typically last up to four months, with most patients engaging in regular treatment sessions to maintain the best results.

Does hyaluronidase dissolve natural hyaluronic acid?

Hyaluronidase is a natural enzyme commonly used to dissolve unwanted hyaluronic acid fillers; however, it can also break down natural hyaluronic acid. The injectable treatment will target the linkages between hyaluronic acids in the designated treatment area, which will consist primarily of hyaluronic acids from fillers. The hyaluronidase will target hyaluronic acid in dermal fillers before dissolving any natural hyaluronic acid. Additionally, hyaluronic acid is a substance that is constantly produced and dissolved by the body as a part of the body’s natural ebb and flow. Even if the hyaluronidase injection dissolves natural hyaluronic acid, your body will be able to restore your natural hyaluronic acid to its pre-filler level in very little time. Dr. Green will determine the appropriate amount of hyaluronidase for each injection based on the amount of dermal filler previously injected. Dr. Green’s experience as a cosmetic injector ensures that the amount of hyaluronidase is safe and appropriate, reducing the risk of unwanted side effects.

Does hyaluronidase dissolve your own collagen?

Hyaluronidase does not dissolve your natural tissue. Though hyaluronidase can dissolve your body’s natural hyaluronic acid, it is not able to dissolve tissue. Hyaluronidase, either naturally occurring within the body or as an injection, breaks down hyaluronic acid and only hyaluronic acid, which is a component found in the skin. Tissue is made of cells that are broken down through different pathways than hyaluronic acid. Occasionally, patients may notice a “depleted” appearance of their skin after hyaluronidase treatment, due to temporary depletion of natural hyaluronic acid. After a hyaluronidase injection, the skin will typically restore its hyaluronic acid levels within a few days or, in rare cases, over a few weeks.

Hyaluronidase: 2 weeks under eyes – before and after

Does hyaluronidase dissolve fat?

Hyaluronidase does not dissolve fat. Hyaluronidase injections are specifically used to break down hyaluronic acid fillers. However, fat cells can be reduced through various non-invasive cosmetic treatments offered by Dr. Green. Kybella is an FDA-approved injectable that targets excess fat and is especially effective for those battling a double chin or stubborn fat around the jawline. It contains a synthetic form of deoxycholic acid, a natural compound that helps break down dietary fat. Kybella can eliminate fat cells near the injection site, preventing further fat buildup. Another popular fat reduction method is CoolSculpting®. This innovative device uses “fat freezing” (Cryolipolysis) to eliminate excess fat. Although not a weight-loss technique, CoolSculpting is ideal for those with stubborn pockets of fat on the abdomen, arms, or under the chin, even if they lead a healthy lifestyle. It works by freezing fat cells at a temperature that spares other tissues, allowing the body to metabolize them. If you’re interested in fat reduction treatments, Dr. Green can evaluate your concerns and develop a personalized plan.

Does hyaluronidase damage the skin?

Hyaluronidase will not affect the skin’s natural collagen or otherwise damage the tissue. Hyaluronidase is specifically used for dissolving hyaluronic acid fillers. Hyaluronidase may dissolve some of the skin’s natural hyaluronic acid, potentially causing a slightly crepey skin texture in the treated area. This crepey skin will resolve on its own after a few days. Side effects of hyaluronidase injections can include tenderness, bruising, and swelling at or near injection sites. It is always recommended to have hyaluronidase injections with an experienced, board-certified dermatologist, such as Dr. Green in New York City, to ensure you achieve the best cosmetic results while minimizing potential side effects. Dr. Green is an expert injector with over 2.5 decades of experience providing some of the world’s most discerning individuals with the best non-invasive treatment options available. If you’ve had dermal fillers that need correction, Dr. Green is here to help.

Does hyaluronidase hurt?

Hyaluronidase injections are relatively pain-free. Some patients report a slight stinging sensation during the injections, which resolves shortly after the injection. Dr. Green will prescribe the lidocaine cream to the pharmacy of your choice. Once you arrive at Dr. Green’s private dermatology office in Manhattan’s Upper East Side neighborhood, the lidocaine cream will be removed, and the skin will be sterilized. Ice packs will be applied to the treated area immediately after the hyaluronidase injections to minimize any swelling or bruising.

Does hyaluronidase cause swelling?

Any injectable treatment, such as dermal fillers, Botox, or hyaluronidase, can result in mild side effects, including bruising, redness, and swelling. In the week leading up to the lip filler dissolving procedure, Dr. Green recommends that patients avoid blood-thinning medications or supplements, as these can increase the risk of bruising or swelling. While patients may experience swelling in the hours after treatment, these side effects typically resolve on their own shortly after treatment.

How far does hyaluronidase spread after being injected?

Hyaluronidase does spread to a certain degree into the tissue. In fact, one of the main roles of hyaluronidase in the medical field is to facilitate the diffusion, or spread, of drugs or agents injected into the tissue. Diffusion is the extent to which a substance spreads. Hyaluronidase is a highly effective substance for medical treatments, as it can increase the permeability of cells and blood vessels through which drugs or chemical agents need to be absorbed, and enhance the dispersion of those drugs or agents. For example, according to a review by Cavallini et al. (https://doi.org/10.1177/1090820X13511970), hyaluronidase is often used during chemotherapy to enhance the permeation of the treatment drug into a malignant tumor. Hyaluronidase can also be used in radiology to enhance the diffusion and absorption of the agent, providing healthcare workers with a clearer view of the treatment area. In ophthalmic surgery and pain therapy, hyaluronidase is also used to help the anesthesia spread throughout the treatment area.

How long to dissolve filler with hyaluronidase?

Patients often wonder, “How long for hyaluronidase to work?” The effects of hyaluronidase will begin to appear within two to three days of the hyaluronidase injections. However, the time required for the full effect of hyaluronic acid filler reversal varies among patients. The majority of patients see complete results from hyaluronidase injections within two weeks. However, some may need two or more weeks to appreciate the results of hyaluronidase treatment. It is best to wait 2 weeks to assess your cosmetic results and determine whether additional hyaluronidase is needed. Hyaluronidase injections can also cause swelling at the injection site.

After hyaluronidase takes full effect, some patients may feel they’d like to boost collagen production through alternative means, such as dermal fillers. In this case, Dr. Green can help develop a revitalizing skincare treatment plan that may include laser resurfacing, radiofrequency devices such as Thermage and Vivace, chemical peels, and microneedling. Dr. Green is an expert in cosmetic dermatology and anti-aging techniques and can help you both look and feel like your best self.

What is the cost of hyaluronidase treatment?

The cost of hyaluronidase varies based on the amount of filler that needs to be dissolved and the injector’s experience. Treatment by a board-certified dermatologist is usually more expensive than with a nurse injector at a spa or clinic; however, having hyaluronidase administered by an experienced, board-certified dermatologist helps ensure you get optimal cosmetic results while emphasizing safety and efficacy. Dr. Michele Green is a globally recognized, board-certified dermatologist and skilled injector with over 25 years of experience offering top non-invasive cosmetic procedures, including hyaluronidase injections and dermal fillers. When you see Dr. Green at her private dermatology practice in Manhattan’s Upper East Side, she will assess the treatment area in person and discuss your specific skin concerns and aesthetic goals to develop a personalized treatment plan. The total cost of your hyaluronidase treatment will be decided during your appointment.

How much hyaluronidase to dissolve lip filler?

While many patients are satisfied with the appearance of lip fillers, some may feel that they did not achieve their desired outcome. Patients may feel dissatisfied due to the work of an inexperienced injector, which can produce adverse outcomes, such as overfilling, asymmetry, filler migration, nodules, and vascular occlusion. In this case, patients can turn to lip filler dissolution, a cosmetic procedure in which hyaluronic acid-based filler is dissolved to return the patient to their natural state. Several factors determine whether patients will need more than one treatment session, including the type and amount of filler used and the filler location. Each type of hyaluronic acid filler contains a different molecular weight and uses a different cross-linking technology to give it structure. The firmer the filler is, the more resistant it is to dissolution, which might require more than one treatment session. Typically, when dissolving lip filler, patients will require five units of hyaluronidase for every 0.1 mL of 20 mg/mL hyaluronic acid filler.

Will hyaluronidase ruin my face?

Not at all! Hyaluronidase injections will destroy any unwanted hyaluronic acid filler, revealing your pre-filler appearance. There are very few adverse effects of hyaluronidase. The most common side effect of hyaluronidase injections is mild swelling and bruising at or near the injection site. The swelling and bruising associated with Hylenex injections will resolve on their own in 1 to 2 weeks. Rarely do some patients have an allergic reaction to the injections, which usually occurs locally as hypersensitivity but can occur as a systemic reaction. Overall, hyaluronidase injections are incredibly safe, with minimal risk of adverse reactions. To confirm the safest and most effective hyaluronidase treatments, you should consult with an expert, board-certified physician, such as Dr. Green. When you consult with Dr. Green, she will physically evaluate your face and review the previous dermal fillers you have received before artfully creating a hyaluronidase treatment plan that caters to your aesthetic needs and goals.

Does hyaluronidase need to be refrigerated?

Hyaluronidase has a relatively short half-life of 2 minutes. However, the action of hyaluronidase lasts 24-48 hours, meaning it takes several days for the full effects of the treatment to become visible. The manufacturers of hyaluronidase recommend storing the solution at 2-8 degrees Celsius to ensure the product remains effective for a long time. When stored at room temperature, the stability of the hyaluronidase treatment can be guaranteed for only 1 year (12 months).

Is hyaluronidase prescription only?

Hyaluronidase is recommended only for patients who are dissatisfied with their dermal filler results or who are prescribed it for certain medical procedures. Hyaluronidase injections should only be performed by an expert injector and medical professional, such as board-certified dermatologist, Dr. Michele Green. To avoid adverse events and serious side effects, always schedule your hyaluronidase injections with an expert.

How to patch test hyaluronidase

Patients concerned about a potential allergic reaction can use a patch test before receiving the full treatment. For a hyaluronidase patch test, Dr. Green will inject a small volume of the substance into the forearm and wait 30 minutes before observing the results. If patients exhibit itching, inflammation, or significant redness at the injection site, they may be experiencing an allergic reaction, and continued treatment should be avoided.

How to dissolve filler without hyaluronidase

Hyaluronidase is the only effective and safe treatment for dissolving hyaluronic acid dermal fillers and reversing their effects, as it degrades hyaluronic acid. Additionally, dermal fillers that are not composed of hyaluronic acid cannot be dissolved with hyaluronidase injections. Patients who have been injected with dermal fillers composed of materials other than hyaluronic acid, such as Radiesse (calcium hydroxylapatite) and Sculptra (poly-L-lactic acid), must wait for the effects of these fillers to wear off over time. For this reason, it is imperative to receive cosmetic injectables from a board-certified cosmetic dermatologist with the expertise and experience to perform your facial rejuvenation. Dr. Green always gives her patients long-lasting, natural-looking results that leave them looking and feeling like their absolute best.

How do I have unwanted dermal fillers dissolved with hyaluronidase today?

Hyaluronidase injections are considered the most effective method for dissolving unwanted or misplaced hyaluronic acid fillers, leading to unsatisfactory cosmetic outcomes. Depending on the type and amount of dermal filler originally used, hyaluronidase injections may require one or multiple treatments to dissolve the filler. After the filler is gone, Dr. Green will evaluate your facial anatomy and develop a personalized dermal filler plan to help you reach your cosmetic goals, ideally avoiding the need to dissolve filler again. If you’ve had hyaluronic acid filler injections with an inexperienced or unqualified injector and are unhappy with the results, hyaluronidase injections with Dr. Green in NYC could be the solution you’ve been looking for.

Dr. Michele Green is an internationally renowned board-certified cosmetic dermatologist with over two and a half decades of experience providing some of the most discerning individuals with the best non-invasive cosmetic treatments available, including dermal fillers and hyaluronidase injections. Taking a holistic approach and embracing a less-is-more philosophy regarding facial rejuvenation, Dr. Green customizes each patient’s treatment protocol to provide a natural-looking, long-lasting, more youthful appearance. Her dedication to her patients and practice is reflected in her consistent selection as one of NYC’s best physicians by Castle Connolly, Super Doctors, and New York Magazine. When you consult with Dr. Green at her private dermatology office in Manhattan’s Upper East Side neighborhood, she will work with you to create a personalized treatment plan that best suits your particular skin concerns and overall aesthetic goals. To schedule a consultation with Dr. Green, contact the office online or call 212-535-3088 today.