Women’s Health Talks With Dr. Green About Botox Tolerance

In this week’s article “Can You Build Up A “Tolerance” To Botox? Dermatologists Reveal The Surprising Answer,” Women’s Health explains that true “resistance” to Botox — meaning the body develops neutralizing antibodies so injections no longer have effect — is possible but very uncommon. For example, they cite a review (Neutralizing Antibody Formation with OnabotulinumtoxinA (BOTOX®) Treatment from Global Registration Studies across Multiple Indications: A Meta-Analysis) of 5,800 patients in which just a small fraction lost responsiveness over time. Most experts quoted in the article stress that in cosmetic use, cases of true immunity are “extremely rare.”

Instead, the article argues the more common reasons for Botox seeming to stop working are factors like incorrect dosing (too few units), improper dilution, or suboptimal injection technique. Facial-muscle strength and anatomy can also change over time — meaning what once was an effective dose might become insufficient later. Thus, fading results often reflect changes in how the treatment is administered or how the body responds, rather than genuine resistance.

Read the full article at https://www.womenshealthmag.com/beauty/a69546090/why-botox-stops-working/